Seymour Duncan SH-16 The 59 Custom BK

Moderate plus plus gain, or High minus minus if you prefer.
Good for saturated rhythm and leads.
Rhythms can be powerful while staying aggressive and alive like a moderate pickup.
Leads are thick so pulloff/hammers are easy, while not being too much compressed so here too it stays aggressive and alive.
Maybe the low end gives that open, natural sound.
The splitted coil (north Custom coil) isn't clear/bright/sharp enough for my ears but it's a rare quality in a bridge humbucker (e.g. I enjoy that split in Jazz bridge or Demon). For that "funk" sound I generally use splitted neck in parallel. Doing that, this pickup delivers perfectly.
Splitted + distortion is quite ok, maybe a small bit too much power for me, anyway I'm not fond of the Custom 5.
So I'd say powerful, still natural and aggressive.