I bought these for my lowered tuned Les Paul, using it in C-tuning and I must say it's perfect! Note: string height, intonation, truss rod adjustment and a little nut filing may be needed... 
 
Pros: 
The strings are a great combination between affordability and durability - at this price you can't complain. They sound great, play great and feel great. 
 
Cons: 
Compared to more expensive alternatives these will, perhaps not, last as long. But if you're anything like me and need to clean the fingerboard quite often this is hardly a problem. When they go dead it's time to clean the guitar anyway... 
 
Conclusion: 
If you use this with a guitar that has a "stop tail" tail piece you can adjust string tension according to taste by adjusting the angle between the bridge and the tail piece. To have a removable nut is preferable, I keep a set of different nuts adapted for different string gauges, and is what I would recommend. It helps with tuning stability. 
 
I've been using GHS strings for all my different guitars for more than 10 years and I probably continue to do so for another 10...